I thought I remember a part from the announcement saying you can do on-device activation. That removes that initial hurdle.
They have two dock adapters for USB and SD card - stated purpose is camera downloads, could be interesting if they would allow transfer of other content via those mechanisms.
You can have access to some non-iTunes Store content (especially in the edu context), if you consider apps like DropBox. Think posting PDFs or images or similar in a public folder and sharing it to students. I would love to see the inter-app document APIs like they opened up for images be opened for other doctypes.